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Structural Biology & Drug Discovery / Professor Ho Sup Yoon's Lab



DESCRIPTION OF LAB RESEARCH WORK
Apoptosis; Molecular chaperones in cancer, malaria, and neurodegenerative diseases; Peptidylprolyl cis-trans isomerases; Nuclear Receptors; Kinases; NMR; Structure-based drug design.
 

LAB MEMBERS
LEAD PI
Yoon Ho Sup
Research Director, Biomedical Sciences
Professor, School of Biological Sciences

Email: hsyoon@ntu.edu.sg
Office: ADM-03-05A/ SBS-02S-96
Phone: (65) ​6316 2846
Lab webpage
Sreekanth Rajan
Senior Research Fellow

Email: srajan@ntu.edu.sg​
Phone: (65) ​6316 2844
Gan Hanjie Jonathan
Research Fellow

Email: jonathan.gan@e.ntu.edu.sg
Phone: (65) ​6316 2844
Toh Hui Ting
Research Fellow

Email: httoh@ntu.edu.sg
Phone: (65) ​6316 2844
Tanvi Parnaik
PhD student

Email: parn0003@e.ntu.edu.sg
Phone: (65) ​6316 2844
Yoo Jun Yeob
Research Fellow

Email: yooj0001@e.ntu.edu.sg
Phone: (65) ​6316 2844


CURRENT PROJECTS
  • Selective inhibitors of VRK1, a mitotic kinase
  • Targeting PGA1-Nurr1 pathway
  • The Spike protein as a crucial tool to design of vaccines, ELISA- based diagnostics and therapeutics
  • Toward development of a new class of anti-malaria drug : molecular characterization and three-dimensional structure determination of plasmodium falciparum FK506-binding protein 35 (PfFKBP35)
  • Understanding Molecular Mechanism of Supradamal, a Novel Adamantanyl-Based Antimalarial Drug
  • Validation of Nurr1 Ligands as Potential PD Therapeutics (Theme 5 - Experimental Therapeutics)
  • Validation of small molecule ligands for Nurr1


PUBLICATIONS
Full list of publications can be found here
  • Rajan, S., Jang, Y., Kim,C-H., Kim, W., Toh, H.T., Jeon, J., Song, B., Serra, A., Lescar, J., Yoo, J.Y., Beldar, S., Liu, X.W., Feitosa, M., Kim, Y., Hwang, D., Goh, G., Lim, K-L., Park, H.M., Lee, C.H., Oh, S.F., Petsko, G.A., Yoon, H.S. and Kim, K.S. (2020). PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function. Nature Chemical Biology, 16, 876-886.
  • Tae-Yoon Park, Yongwoo Jang, Woori Kim, Joon Shin, Hui Ting Toh, Chun-Hyung Kim, Ho Sup Yoon, Pierre Leblanc and Kwang-Soo Kim. (2019). Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases. Scientific Reports, 9(1), 15559.
  • Kim CH, Han, BS, Moon J, Kim DJ, Shin J, Rajan S, Toh HT, Sohn M, Kim WG, Han M, Jeong I, Kim KS, Lee EH, TU, Y, Naffin-Olivos JL, Park CH, Ringe D, Yoon HS, Petsko GA, and Kim KS (2015) Agonists for Nurr1 enhance its contrasting dual functions and ameliorate Parkinson-related phenotypes. Proc. Natl. Acad. Sci. USA. 112, 8756-8761.
  • Prakash A, Shin J, Rajan S, Yoon HS. (2016). Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin. Nucleic Acids Research, 44(4), 2909-25.
  • Beldar S, Manimekalai MSS, Cho NJ, Baek B, Gruber G, Yoon HS (2018) Self-association and conformational variation of NS5A domain 1 of hepatitis C virus. J Gen Virol. 99, 194-208.
  • Kim CH, Han BS, Moon J, Kim DJ, Shin J, Rajan S, Nguyen QT, Sohn M, Kim WG, Han M, Jeong I, Kim KS, Lee EH, Tu Y, Naffin-Olivos JL, Park CH, Ringe D, Yoon HS, Petsko GA, Kim KS. (2015). Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America, 112(28), 8756-61.
  • Rajan S, Choi M, Nguyen QT, Ye H, Liu W, Toh HT, Kang CB, Kamariah N, Grüber G, Li C, Huang H, White C, Baek K, and Yoon HS (2015) Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport. Sci Rep. 5:10609.
  • Harikishore A, Niang M, Rajan S, Preiser PR, Yoon HS. (2013) Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent. Sci Rep. 3:2501.
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