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Resilieo (Neurobiology of Stress-Resilience)



DESCRIPTION OF LAB RESEARCH WORK

Neurobiology of Resilience
Stress targets everyone; but not everybody succumbs to it. Some develop stress-related psychopathology, anxiety, depression, dementia, while others weather it well and even emerge healthier. What makes some individuals resilient and others not? Comprehensive studies on 9/11 survivors and war veterans report that positive emotion helps resilient people re-route physiological resources activated by stress into successful coping strategies. Stress is known to cause brain damage, shrink neurons of hippocampus (memory center of brain) and enhance emotional learning along with neuronal growth in amygdala (emotion center of brain). Our research (@ Resilieo) is geared to find out how we can minimize brain damage caused by stress.
  • Is there any difference in brains of resilient and vulnerable individuals?
  • How to rescue or prevent stress-induced damages (enhance resilience)?
  • Developing animal model of resilience
  • Are resilient individuals better adapted?
Lab Page: http://home.resilieo.com/home/example-content-page

LAB MEMBERS
LEAD PI
Asst Prof Rupshi Mitra
Assistant Professor

Email: rmitra@ntu.edu.sg
Phone: (65) 6513 8043
Office: SBS-02N-09
Shruti Suresh
Project Officer

Email: shruti.suresh@ntu.edu.sg


CURRENT PROJECTS
  • Connectivity of Ventromedial Prefrontal Cortex in Simple and Complex Housing Living Environment
    This project investigates how brain connections between different regions change with the change in environment. Here we study tracing of different neuronal tracts within brain network.

  • Defining the Brain Circuitry Defects that cause Dementia
    As part of Tier 3 grant, we investigate primary brain pathways and defects in animal models with genetic manipulation.

  • How does Enriched Environment promote Resilience? In search of Brain Mechanisms
    In this project we aim to delineate specific molecular events that characterize a resilient individual/population from a vulnerable one.

  • Neuroscience of Psychological Resilience
    Preparation and validation of a concept inventory at the intersection of Neuroscience and Biological Psychology​


PUBLICATIONS
Full list of publications can be found here
  • Enriched Environment Facilitates Anxiolytic Efficacy Driven by Deep-Brain Stimulation of Medial Prefrontal Cortex.
    https://www.frontiersin.org/articles/10.3389/fnbeh.2018.00204/full
    Yamini Bhaskar, Lee Wei Lim, Rupshi Mitra Front. Behav. Neurosci., 09 October 2018 |
    https://doi.org/10.3389/fnbeh.2018.00204
  • Short environmental enrichment in adulthood reverses anxiety and basolateral amygdala hypertrophy induced by maternal separation.
    Koe AS, Ashokan A, Mitra R.
    Transl Psychiatry. 2016 Feb 2;6:e729. doi: 10.1038/tp.2015.217.
    https://www.nature.com/articles/tp2015217
  • Complex housing causes a robust increase in dendritic complexity and spine density of medial prefrontal cortical neurons.
    Ashokan A, Lim JWH, Hang N, Mitra R.
    Sci Rep. 2018 May 9;8(1):7308. doi: 10.1038/s41598-018-25399-4.
    https://f1000.com/prime/733211700?bd=1
    F1000 - Post-publication peer review
  • Mineralocorticoid receptor overexpression in basolateral amygdala reduces corticosterone secretion and anxiety.
    Mitra R, Ferguson D, Sapolsky RM.
    Biol Psychiatry. 2009 Oct 1;66(7):686-90. doi:
    10.1016/j.biopsych.2009.04.016. Epub 2009 Jun 5.
  • Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy.
    Mitra R, Sapolsky RM.
    Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5573-8. doi:
    10.1073/pnas.0705615105. Epub 2008 Apr 7.
  • Stress coping stimulates hippocampal neurogenesis in adult monkeys.
    Lyons DM, Buckmaster PS, Lee AG, Wu C, Mitra R, Duffey LM, Buckmaster CL, Her S, Patel PD, Schatzberg AF.Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14823-7. doi:
    10.1073/pnas.0914568107. Epub 2010 Jul 30.
  • ​Mineralocorticoid receptor overexpression in basolateral amygdala reduces corticosterone secretion and anxiety.
    Mitra R, Ferguson D, Sapolsky RM. Biol Psychiatry. 2009 Oct 1;66(7):686-90. doi:
    10.1016/j.biopsych.2009.04.016. Epub 2009 Jun 5.
  • Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy. Mitra R, Sapolsky RM.
    8;105(14):5573-8. doi:
    10.1073/pnas.0705615105. Epub 2008 Apr 7.
  • Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala.
    Mitra R, Jadhav S, McEwen BS, Vyas A, Chattarji S.
    Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9371-6. Epub 2005 Jun 20.
  • Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons.
    *Vyas A, *Mitra R, Shankaranarayana Rao BS, Chattarji S. (*Equal authorship)
    J Neurosci. 2002 Aug 1;22(15):6810-8.
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