Laboratory of Cell Cycle and Cancer Biology
The cell cycle is the set of sophisticated self-regulated mechanisms by which cells make copies of themselves with same genome. Misregulation of the cell cycle may result in cancer. Our lab focuses on: 1. The mechanism on how genome integrity is regulated during the cell cycle in general; 2. Regulation of mitotic catastrophe/cell death in cancer treatment; 3. Impact of metabolic reprogramming on genomic integrity during cancer development; 4. Natural products drug development for cancer treatment; and 5. Maintenance of genome integrity in Malaria parasite during the intraerythrocytic cycle. We are also interested in developing imaging techniques and modeling to tackle problems.
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Movie 1. Nomrla mitotic bipolar spindle (Left). Monopolar spindle induced by anticancer drug (Right) |

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Movie 2. Mitotic cell death after treatment of anticancer drug Taxol |

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Movie 3. Knockdown of VCP (AAA ATPase p97) inhibits actin dynamic in cancer cells |
LAB MEMBERS
PUBLICATIONS
(Full list of publications can be found here)
- N.Z.J. Khong, S.K. Lai, S.G. Shochat, C.G. Koh and H.Y.Li (2019). AAA-ATPase p97/VCP regulates actin cytoskeleton through Plk1-dependent phosphorylation of ROCK. Oncotarget. 11(1): 74–85. doi: 10.18632/oncotarget.27419
- L. Xin, Y Zeng, S. Sheng, R.A. Chea, Q. Liu, H.Y. Li, L. Yang, K.H. Chiam, Z.X. Liang (2019). Regulation of flagellar motor switching by c-di-GMP phosphodiesterases in Pseudomonas aeruginosa. Journal of Biological Chemistry. 294:37 P13789-13799.
- S. Sheng, L. Xin, J.K.H. Yam, M.M.S. Salido, N.Z.J. Khong, Q. Liu, R.A. Chea, H.Y. Li, L. Yang, Z.X. Liang, and L. Xu (2019) C-di-GMP Regulates the Methylation of Multiple Chemoreceptors via the MapZ Adaptor Protein to Influence the Pathogenesis of Pseudomonas Aeruginosa . Frontiers in Microbiology, section Infectious Diseases 2019 Feb 5;10:67. doi: 10.3389/fmicb.2019.00067
- T. Wunder., S.C.L. Hung, S.K. Lai, H.Y. Li, and O.M. Cajar (2018). The phase separation underlying the pyrenoid-based microalgal Rubisco supercharger, Nature Communication 29 Nov 2018 https://doi.org/10.1038/s41467-018-07624-w
- L.F. Zhang, N. Ha, L.T. Lai, R. Chelliah, Y. Chelliah, Seet P.Y. Vanessa, S.K. Lai, H.Y. Li, A. Ludwig, S. Sandin, and L. Chen. (2018) Live-cell imaging and functional dissecting of Xist RNA reveal mechanisms of X chromosome inactivation and reactivation. iScience, Oct 26;8:1-14. doi: 10.1016/j.isci.2018.09.007. Epub 2018 Sep 13.
- S. Ou, M.H. Tan, T. Weng, H.Y. Li and C.G. Koh (2018) LIM kinase1 regulates mitotic centrosome integrity via its activity on dynein light intermediate chains. Open Biology. Published 20 June 2018.DOI: 10.1098/rsob.170202
- P.J. Shi, Y.S.E. Tan, W.Y. Yeong, H.Y. Li, and A. Laude (2018). A bilayer photoreceptor-retinal tissue model with gradient cell density design: a study of microvalve-based bioprinting. Journal of Tissue Engineering an d Regenerative Medicine. DOI: 10.1002/term.2661.
- Y. Aniweh, X. Gao, P. Hao, W. Meng, S.K. Lai, K. Gunalan, T.T. Chu, A. Sinha, J. Lescar, R. Chandramohanadas, H.Y. Li, S.K. Sze,, and P.R. Preiser, (2017) RH5-Basigin interaction induces changes in the cytoskeleton of the host RBC, Cellular Microbiology. Sep;19(9). doi: 10.1111/cmi.12747. Epub 2017 May 9.
- Q.Y. Wong, N. Liu, C.G. Koh H.Y. Li and W.S. Lew (2016) Isolation of magnetically tagged cancer cells through an integrated magnetofluidic device, Microfluidics and Nanofluidics, 20(10), 1-9.
- J.L. Hoon, H.Y. Li, and C.G. Koh (2014). POPX2 phosphatase regulates cell polarity and centrosome placement, Cell Cycle, 13(15), 2459-2468.
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