Professor James P. Tam's Laboratory

1. Discovery, design and synthesis of orally active peptides, herbalomics and molecular diversity in medicinal plants and functional foods.
2. Peptide and protein chemistry, selective chemoenzymatic ligation for peptides, proteins and dendrimers, synthesis and oxidative folding of cysteine-rich peptides.

	LEAD PI Jimmy P Tam Professor Email: jptam@ntu.edu.sg Phone: (65) 6316 2833 Office: SBS-03S-71
	Dr Bamaprasad Dutta Research Fellow Email: BDutta@ntu.edu.sg
	Dr He Muxinya Research Fellow Email: HEMUXINYA@ntu.edu.sg
	Dr Janet To Yiu Ying Research Fellow Email: janetto@ntu.edu.sg
	Dr Ka Ho Wong Research Fellow Email: hwka@ntu.edu.sg
	Dr Kam Antony Research Fellow Email: k.antony@ntu.edu.sg
	Dr Loo Shining Research Fellow Email: snloo@ntu.edu.sg​
	Warren Lee Xian Liang (Dr) Research Fellow Email: WARREN.LEE@ntu.edu.sg
	Dr Zhang Xiaohong Research Fellow Email: zhangxh@ntu.edu.sg​
	Mdm Yee Lee Choo Project Officer Email: elcyee@ntu.edu.sg​
	Mr Leonard Chan Huang Yoon Research Assistant Email: leonard.chan@ntu.edu.sg​
	Ning-Tu Chan PhD candidate Email: ningyu001@e.ntu.edu.sg
	Mr Shaun Tan Jun Hao Graduate Research Officer Email: shauntan@ntu.edu.sg​

• Discovery of Druggable Biologics from Medicinal Plants
• Large-scale Conversion of Wastes to Functional Food and High-value Products
• Discovery, Engineering and Applications of Peptide Ligases
• Mode-of-Action of Druggable Biologics from Medicinal Plants
• Mechanisms of Active ligases

• Vascular Bed Molecular Profiling by Differential Systemic Decellularization In Vivo
• One-pot dual labeling of an IgG 1 and preparation of C-to-C fusion proteins through a combination of Sortase A and Butelase 1
• Ginsentides: Cysteine and Glycine-rich Peptides from the Ginseng Family with Unusual Disulfide Connectivity
• Plant-derived Mitochondria-targeting Cysteine-rich Peptide Modulates Cellular Bioenergetics
• Astratides: insulin-modulating, insecticidal and antifungal cysteine-rich peptides from Astragalus membranaceus
• Ligase-controlled Cyclo-oligomerization of Peptides
• Pulsed SILAC-based proteomic analysis unveils hypoxia- and serum starvation-induced de novo protein synthesis with PHD finger protein 14 (PHF14) as a hypoxia sensitive epigenetic regulator in cell cycle progression
• Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift
• Immobilization and Intracellular Delivery of Circular Proteins by Modifying a Genetically Incorporated Unnatural Amino Acid
• Molecular diversity and function of jasmintides from Jasminum sambac