Professor James P. Tam's Laboratory
DESCRIPTION OF LAB RESEARCH WORK
- Discovery, design and synthesis of orally active peptides, herbalomics and molecular diversity in medicinal plants and functional foods.
- Peptide and protein chemistry, selective chemoenzymatic ligation for peptides, proteins and dendrimers, synthesis and oxidative folding of cysteine-rich peptides.
LAB MEMBERS
CURRENT PROJECTS
- Discovery of Druggable Biologics from Medicinal Plants
- Large-scale Conversion of Wastes to Functional Food and High-value Products
- Discovery, Engineering and Applications of Peptide Ligases
- Mode-of-Action of Druggable Biologics from Medicinal Plants
- Mechanisms of Active ligases
PUBLICATIONS
Full list of publications can be found here
- Vascular Bed Molecular Profiling by Differential Systemic Decellularization In Vivo
- One-pot dual labeling of an IgG 1 and preparation of C-to-C fusion proteins through a combination of Sortase A and Butelase 1
- Ginsentides: Cysteine and Glycine-rich Peptides from the Ginseng Family with Unusual Disulfide Connectivity
- Plant-derived Mitochondria-targeting Cysteine-rich Peptide Modulates Cellular Bioenergetics
- Astratides: insulin-modulating, insecticidal and antifungal cysteine-rich peptides from Astragalus membranaceus
- Ligase-controlled Cyclo-oligomerization of Peptides
- Pulsed SILAC-based proteomic analysis unveils hypoxia- and serum starvation-induced de novo protein synthesis with PHD finger protein 14 (PHF14) as a hypoxia sensitive epigenetic regulator in cell cycle progression
- Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift
- Immobilization and Intracellular Delivery of Circular Proteins by Modifying a Genetically Incorporated Unnatural Amino Acid
- Molecular diversity and function of jasmintides from Jasminum sambac
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