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Professor James P. Tam's Laboratory

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DESCRIPTION OF LAB RESEARCH WORK
  1. Discovery, design and synthesis of orally active peptides, herbalomics and molecular diversity in medicinal plants and functional foods.
  2. Peptide and protein chemistry, selective chemoenzymatic ligation for peptides, proteins and dendrimers, synthesis and oxidative folding of cysteine-rich peptides.

LAB MEMBERS
LEAD PI
Jimmy P Tam
Professor

Email: jptam@ntu.edu.sg
Phone: (65) 6316 2833
Office: SBS-03S-71
Dr Bamaprasad Dutta
Research Fellow

Email: BDutta@ntu.edu.sg
Dr He Muxinya
Research Fellow

Email: HEMUXINYA@ntu.edu.sg
Dr Janet To Yiu Ying
Research Fellow

Email: janetto@ntu.edu.sg
Dr Ka Ho Wong
Research Fellow

Email: hwka@ntu.edu.sg
Dr Kam Antony
Research Fellow

Email: k.antony@ntu.edu.sg
Dr Loo Shining
Research Fellow

Email: snloo@ntu.edu.sg​
Warren Lee Xian Liang (Dr)
Research Fellow

Email: WARREN.LEE@ntu.edu.sg
Dr Zhang Xiaohong
Research Fellow

Email: zhangxh@ntu.edu.sg​
Mdm Yee Lee Choo
Project Officer

Email: elcyee@ntu.edu.sg​
Mr Leonard Chan Huang Yoon
Research Assistant

Email: leonard.chan@ntu.edu.sg​
Ning-Tu Chan
PhD candidate

Email: ningyu001@e.ntu.edu.sg
Mr Shaun Tan Jun Hao
Graduate Research Officer

Email: shauntan@ntu.edu.sg​

CURRENT PROJECTS
  • Discovery of Druggable Biologics from Medicinal Plants
  • Large-scale Conversion of Wastes to Functional Food and High-value Products
  • Discovery, Engineering and Applications of Peptide Ligases
  • Mode-of-Action of Druggable Biologics from Medicinal Plants
  • Mechanisms of Active ligases

PUBLICATIONS
Full list of publications can be found here
  • Vascular Bed Molecular Profiling by Differential Systemic Decellularization In Vivo
  • One-pot dual labeling of an IgG 1 and preparation of C-to-C fusion proteins through a combination of Sortase A and Butelase 1
  • Ginsentides: Cysteine and Glycine-rich Peptides from the Ginseng Family with Unusual Disulfide Connectivity
  • Plant-derived Mitochondria-targeting Cysteine-rich Peptide Modulates Cellular Bioenergetics
  • Astratides: insulin-modulating, insecticidal and antifungal cysteine-rich peptides from Astragalus membranaceus
  • Ligase-controlled Cyclo-oligomerization of Peptides
  • Pulsed SILAC-based proteomic analysis unveils hypoxia- and serum starvation-induced de novo protein synthesis with PHD finger protein 14 (PHF14) as a hypoxia sensitive epigenetic regulator in cell cycle progression
  • Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift
  • Immobilization and Intracellular Delivery of Circular Proteins by Modifying a Genetically Incorporated Unnatural Amino Acid
  • Molecular diversity and function of jasmintides from Jasminum sambac
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